John Stossel on FOX thinks that no people have been treated as well by the American government than American Indians.
Trail of Tears: The forced march of Cherokee (and others) from Georgia to Oklahoma. Thousand died in what history records as an act of genocide.
Bear River Massacre: 1863, Union soldiers killed every man, woman, and child, 490 in all, in a Shoshone village near what is now Preston, ID.
Sand Creek Massacre: In the 1860's Col. John Chivington of the US cavalry waged a war of extermination against Native Americans in eastern Colorado. In the battle of Sand Creek, his troopers attacked a peaceful village killing every living soul there and scalping the bodies. Col. Chivington kept over 100 trophy scalps as well as the pubic hair of women victims. Col. Chivington famously defended killing babies by saying, "Nits make lice."
Wounded Knee: In the winter of 1890, American soldiers attacked a starving Lakota Sioux encampment of 350, two-thirds women and children. This is considered the last "battle" of the Indian Wars.
Boarding Schools: Well into the 20th century it was the practice of the Bureau of Indian Affairs to take Native American children away from their families and place them in boarding schools. There they would be purged of the indian-ness, they would be forced to practice Christianity and punished for speaking their native languages. Vicious beatings and sexual abuse was common.
Poverty: While some tribes have prospered because of Indian casinos, most Native Americans continue to live in horrible poverty with unemployment rates well over 50%.
Poisoning: One alternative to poverty is allowing resource mining on tribal lands. Native Americans suffer to a far greater degree than the general population from uranium, lead, and mercury poisoning.