The Afghan War's targeted killing program sounds a lot like the old Search and Destroy operations in Vietnam.
One of the persistent fallacies of American military strategy is the belief that guerrilla forces require the same inflexible, top-down, chain-of-command structure to operate as the US armed forces need. If only we kill their generals, think our generals, they will be helpless. It's silly, really. Guerrilla wars, by their nature, lack a central command to behead.